FABIAhttp://mloss.orgUpdates and additions to FABIAenFri, 18 Oct 2013 10:14:57 -0000FABIA 2.8.0<html><p>Biclustering by "Factor Analysis for Bicluster Acquisition" (FABIA). FABIA is a model-based technique for biclustering, that is clustering rows and columns simultaneously. Biclusters are found by factor analysis where both the factors and the loading matrix are sparse. FABIA is a multiplicative model that extracts linear dependencies between samples and feature patterns. FABIA ranks biclusters according to their information content and separates spurious biclusters from true biclusters. </p> <p>FABIA is an R package while the code is written in C. </p> <p>Applications: </p> <ul> <li> microarray: genes that are diffentially expressed in certain samples form a bicluster with these samples, e.g. genes of a pathway that is activated in certain samples. </li> <li> genetics: researchers want to identify haplotypes shared by different individuals due to &gt;identity by descent&lt;. Especially rare variants in next generation sequencing that form an identity by descent block are identified by fabia (spfabia).<br /> </li> </ul></html>Sepp HochreiterFri, 18 Oct 2013 10:14:57 -0000 factorizationsparse learningvariational inferencebiclusteringgene expression